genomics.senescence.infoHuman Ageing Genomic Resources

Genomics GenAge A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. Search human Search model organisms GenDR A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling. Search gene manipulations Search gene expression LongevityMap Database of human genetic variants associated with longevity. Search genes/variants CellAge Database of human genes associated with cellular senescence. Search CellAge Search signatures Gene Expression Projects focused on gene expression profiling of ageing and of dietary manipulations of ageing, such as caloric restriction. Genomes Information on developing genomic resources and methods for studying long-lived species. Cancer Studies focused on cancer, in particular using genomics and bioinformatics approaches. Software Software for ageing research, including the Ageing Research Computational Tools (ARCT) perl toolkit. Drugs DrugAge A curated database of compounds that modulate longevity in model organisms. Search Animal Longevity AnAge A curated database of ageing and life history information in animals, including extensive longevity records. Search AnAge Naked Mole-Rat Genome Resource The benchmark genome assembly and annotation of the long-lived, cancer-resistant naked mole-rat ( Heterocephalus glaber ). Bowhead Whale Genome Resource A high-coverage genome of the bowhead whale ( Balaena mysticetus ), the longest-lived mammal. Evolution Analyses using the AnAge database to study the evolution of longevity and ageing in vertebrate lineages. Ageing Changes Digital Ageing Atlas A portal of ageing changes covering different biological levels, integrating molecular, physiological and pathological age-related data. Search Ageing Information senescence.info An educational and information resource on the science of ageing. Follow @AgingBiology LibAge (beta) The bibliographic library for ageing research. Search literature Who’s Who in Gerontology The WhosAge database contains people and biotech companies that are contributing to increase our understanding of ageing and life-extension. Search companies Search people Genomics of Ageing and Rejuvenation Lab Our lab leads the upkeep and development of HAGR. Search all databases: Quick Search at senescence.info Genomics GenAge GenDR LongevityMap Gene Expression CellAge Cancer Ageing Diseases Genomes Evolution Software Drugs DrugAge Animal Longevity AnAge Ageing Changes Digital Ageing Atlas The (HAGR) is a collection of databases and tools designed to help researchers study the genetics of human ageing using modern approaches such as functional genomics, network analyses, systems biology and evolutionary analyses. Search HAGR Search a single gene, a list or leave blank for all HAGR genes. Search for genes News Follow @AgingBiology Tweets by @AgingBiology GenAge A major resource in HAGR is GenAge , which includes a curated database of over 300 genes related to human ageing and a database of over 2,000 ageing- and longevity-associated genes in model organisms . Search human genes Search model organism genes AnAge Another major database in HAGR is AnAge . Featuring over 4,000 species, AnAge provides a compilation of data on ageing, longevity, and life history that is ideal for the comparative biology of ageing. Search species DrugAge DrugAge provides data on over 500 ageing-related drugs across model organisms. Search drugs GenDR GenDR is a database of genes associated with dietary restriction based on genetic manipulation experiments and gene expression profiling. Search gene manipulations Search gene expression LongevityMap The LongevityMap is a database of human genetic variants associated with longevity. Over 2,000 genes and variants previously studied in context of longevity are featured. Search genes and variants CellAge CellAge is a database of human senescence-associated genes based on genetic manipulations experiments plus gene expression profiling.HAGR by Organism All the genes across the HAGR databases can be browsed by organism using the links below Caenorhabditis elegans Drosophila melanogaster Mus musculus Saccharomyces cerevisiae Other Datasets, Tools and Projects Other projects we are involved in include drugs and compounds , evolutionary studies , genome sequencing , cancer genomics , and gene expression analyses . The latter allowed us to identify a set of genes commonly altered during mammalian ageing which represents a conserved molecular signature of ageing . In addition to developing datasets and performing numerous analyses we develop computational tools and software , including a Perl toolkit entitled the Ageing Research Computational Tools (ARCT) , and a method to calculate the rate of ageing of a given population based on demographic parameters . If you are interested in the genomics of ageing, please spare a moment to read our scientific strategy . For an introduction and description our resources please refer to our latest academic publication . In case you are lost, you can visit our help section or get an overview of all data in our resources. You can also learn more about our projects and the people responsible , and please remember to read our disclaimer and copyright . Usage of HAGR or any of its associated resources implies you have read, understood, and accepted our terms and conditions and will abide by them. Lastly, we have an extensive list of links regarding computational biology, genomics, gerontology, and comparative biology. HAGR is employed by numerous researchers around the world and has been cited in hundreds of publications . It was highlighted in Science ( 307 :187), Nature Reviews Genetics ( 5 :1362), and BioTechniques ( 39 :21). Feedback on all aspects of HAGR is always appreciated. To receive the latest news and announcements concerning HAGR, please join the HAGR-news mailing list . To stay up-to-date with the discoveries and papers on the science of ageing, please follow us on Twitter or like our Facebook page. HomeDisclaimer Downloads Feedback Help Links Mailing List News Publications Science Databases Gene Database (GenAge) Species Database (AnAge) Dietary Restriction Database (GenDR) Longevity Variants Database (LongevityMap) Cell Senescence Database (CellAge) Drugs Database (DrugAge) External Databases Digital Ageing Atlas LibAge (beta version) Projects Gene Expression Cancer Genome Sequencing Evolution of Ageing Software Information and News senescence.info Genomics of Ageing and Rejuvenation Lab Follow @AgingBiology Events 2017 Ageing Genomics and Bioinformatics Workshop Comments, suggestions, ideas, and bug reports are welcome. Please contact us . HAGR may be freely used for all purposes under some conditions...